0], given that, where [gamma] is the duration of the incubating period, [alpha] is the duration of the symptomatic period, and [tau] is the doubling time
This is roughly equivalent to a PSA doubling time
of less than 3 years in patients with PSA levels between 5.
The median pre-treatment PSA doubling time
in the high-dose group was 2.
Although designed primarily as a safety study, it was observed that patients in the high dose group experienced a statistically significant increase in their PSA doubling time
during the post-vaccination period when telomerase-specific T-cells were present.
Of 9 patients evaluable for PSA doubling time
Dendreon Corporation (Nasdaq:DNDN) announced that preliminary results from a Phase 2 trial, P-16, indicate that a combination therapy of Provenge(R) and Bevacizumab (Avastin(TM)) has demonstrated evidence of decreasing PSA doubling time
in men with androgen dependent prostate cancer.
These results suggest that exisulind as a single-agent is capable of prolonging PSA doubling time
over 24 months, with manageable toxicity in patients at high risk of prostate cancer progression," said Dr.
Results of the extension study show that Aptosyn(R) treatment continues to significantly increase PSA doubling time
(indicative of a slowing of disease progression) during a 24-month time period with manageable toxicity, in patients at high risk of prostate cancer recurrence.
The results of the Phase II/III study, involving 96 patients at multiple centers throughout the United States, demonstrated that exisulind inhibited the rise in PSA (prostate specific antigen) levels in treated men overall and significantly prolonged PSA doubling time
in high-risk patients compared with placebo.
In addition, exisulind therapy significantly prolonged the median PSA doubling time
in "high risk" patients compared to placebo-treated men (p=0.
The researchers observed that control tumors in untreated mice grew with a doubling time
The availability of epothilone for clinical evaluation has been severely limited by the poor productivity and slow doubling time
of the epothilone-producing organism, Sorangium cellulosum.
Conversely, the same mammalian telomeric hexanucleotide has now been shown to inhibit telomerase activity in cell lysates, lengthen cell doubling time
, and induce apoptosis in a variety of cancer cells.
Severe acute respiratory syndrome: temporal stability and geographic variation in case-fatality rates and doubling times
To stave off the collapse of our complex society we should request planning exercises that invoke once-in-100-year and once-in-500-year droughts, the probable effects of global warming in California's latitudes, and a time horizon of 90 years (two population doubling times
at the present rate).