There are insects that just laugh at naked double-stranded RNA
," he says.
The production of double-stranded RNA
under the process results in vivo stability, thereby causing a considerable increase in potency compared to the intrinsically unstable dsRNA.
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA
in Caenorhabditis elegans.
The small conditional RNAs trick cancer cells into self-destructing by selectively forming long double-stranded RNA
polymers that mimic viral RNA.
Ten double-stranded RNA
genome segments were separated by electrophoresis, showing a pattern typical of ARV with the S1 segment migrating between S- and M-segment classes (5).
In the late 1980s, geneticist Richard Jorgensen, then working at a California plant biotechnology company, attempted to deepen the hue of purple petunias by introducing more of the gene that gives them their color, in the form of double-stranded RNA
Objective: "RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA
They also knew that RIG-I was usually active in the presence of double-stranded RNA
, not the single-stranded RNA found in most animal cells.
Segmented double-stranded RNA
viruses; structure and molecular biology.
Working in the mid-1990s with a roundworm, Fire and Mello found that double-stranded RNA
with a given sequence shuts down protein production of the gene with a matching sequence.
Binding of the influenza virus NS1 protein to double-stranded RNA
inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor.
RNAi is induced by small, double-stranded RNA
In the RNAi pathway, long pieces of double-stranded RNA
are cut into smaller pieces by the "dicer" enzyme to form small interfering RNAs (siRNAs) that are about 21 nucleotides long.
Herpes simplex virus 1 (HSV-1), which causes cold sores, uses a short, double-stranded RNA
to outwit a cell's defensive measures.
Synthetic double-stranded RNA
poly(I:C) combined with mucosal vaccine protects against influenza virus infection.