The augmented activity of the dopaminergic system
in response to exercise initiation appears to be due to an increase in the central levels of calcium, which increases the activity of tyrosine hydroxylase through the activation of the calcium-calmodulin system (64).
Changes in neurochemical transmission within the dopaminergic system
, especially through dopamine D2 receptors are of critical importance for both emergence of schizophrenia and its current treatment with antipsychotic drugs [7, 8].
Thus, acute treatment should consist of preferential blocking of postsynaptic NAc DA receptors (D1-D5), whereas long-term activation of the mesolimbic dopaminergic system
should involve activation and/or release of DA at the NAc site.
Also, the antidepressive action may be dependent on the serotonergic, noradrenergic and dopaminergic systems
It has gone through several iterations but in general suggests that schizophrenia is caused by dopaminergic system
dysfunction, particularly increased dopamine within subcortical brain regions such as the striatum or nucleus accumben.
elegans can be exploited as a model to study obesity and neurodegeneration, with a particular focus on environmental toxins and their role within the dopaminergic system
Spontaneous eye-blink rates and dopaminergic systems
Implication of nucleus accumbens and dopaminergic system
in the neuropharmacological actions of antidepressant therapies
These data suggest that dopaminergic systems
play a similar role in the responses of rodents and Drosophila to acute alcohol exposure.
11-18) Similarities between disorders of increased serotonergic activity and disorders of low dopaminergic activity (Table 1) suggest both may result from an imbalance between the serotonergic and dopaminergic systems
, which have reciprocal relationships in the CNS.
Though the findings are still preliminary, they are in accord with a growing body of data indicating that the glutaminergic and GABAergic neuron systems may be as important in the etiology of depression as are the more commonly targeted serotonergic and dopaminergic systems
, he said.
Selective vulnerability of dopaminergic systems
to industrial chemicals: risk assessment of related neuroendocrine changes.
Hence, they will have access to other brain dopaminergic systems
and their postsynaptic receptors which form the nigrostriatal and mesolimbic dopaminergic systems
Some of the metabolic abnormalities observed in the brains of the abusers could be a result of effects on dopaminergic systems
, considering many of the regions selected for comparison have dopaminergic innervation, the investigators hypothesized.
Heavy metals polluting the environment can cause subtle effects on children's renal and dopaminergic systems
without clear evidence of a threshold, which reinforces the need to control and regulate potential sources of contamination by heavy metals.