Thus, acute pharmacological adjunctive treatment should consist of preferential blocking of postsynaptic NAc DA receptors (D1-D5), whereas long-term activation of the mesolimbic dopaminergic system
should involve activation and/or release of DA at the NAc site.
To verify the effect of FRA's antidepression over serotonergic, noradrenergic and dopaminergic system, the anti-immobility effect of FRA in FST was prevented by pre-treatment of rat with their receptor antagonists.
Involvement of the serotonergic, noradrenergic and dopaminergic system in the antidepressant effect of FRA in FST
The role of genetic variants of the dopaminergic system
in heroin dependence.
1 million to fund 11 research projects studying the molecular and cellular signals that produce and maintain the midbrain dopaminergic system
that degenerates in Parkinson's disease.
In conclusion, our data show that heavy metals polluting the environment can cause subtle effects on the children's renal and dopaminergic systems
Growing evidence suggests that greater insight into the entire dopaminergic system
, including its development, will increase understanding of Parkinson's disease and heighten the likelihood of successfully developing new therapies, particularly those involving stem cells.
Combined exposure thus potentiated effects that appear to target the nigrostriatal dopaminergic systems
noradrenergic and/or dopaminergic systems
in the brain which have been
Collectively, these studies demonstrate that ATR can produce neurotoxicity in dopaminergic systems
that are critical to the mediation of movement as well as cognition and executive function.
For example, there is preliminary evidence that a bacterial stimulus (endotoxin) can produce cytokines that impair the development of the mesencephalic dopaminergic systems
In 1983, Spear and Brake (113) brought attention to changes in dopaminergic systems
during adolescence in a thorough review.
Most current therapies target the dopaminergic system
that is implicated in the pathogenesis of PD, and most current treatments act by increasing dopaminergic transmission that leads to amelioration of motor symptoms.