Physicians who prescribe dopamine agonists
should vigilantly monitor their patients, and ensure that patients, families, and caregivers are counseled about [this] risk," the investigators wrote.
Behaviors such as compulsive shopping, eating, gambling, and sexual behaviors are a known complication of dopamine agonist
use in PD (Weintraub & Nirenberg, 2013).
Food and Drug Administration (FDA) from being a monotherapy and adjunct to levodopa (LD) to now being an adjunct to dopamine agonists
Anyone receiving treatment with a dopamine agonist
, or caring for someone receiving this treatment, who notices unusual behaviours, such as new or increased gambling urges, increased sexual urges or other intense urges should talk to their doctor.
The completed 015 study: a phase III, double-blind, placebo-controlled six-month study to evaluate efficacy and safety of a low (50-100mg/day) and high (150-200mg/day) dose range of safinamide as add-on to dopamine agonist
therapy versus dopamine agonist
therapy alone in early stage PD patients.
We present three macroprolactinemic patients whose hyperprolactinemic symptoms were improved after treatment with dopamine agonists
The drugs in question in the study--pergolide (Permax [R]) and cabergoline (Dostinex [R])--are categorized as dopamine agonists
, a class of drugs that increase production of the brain neurotransmitter dopamine while decreasing production of the pituitary hormone prolactin.
The patient is currently not on dopamine agonist
therapy, and although her total prolactin levels remain significantly elevated, her free prolactin levels have been in the normal range.
Until now, patients have mostly taken a dopamine agonist
- an agent that acts directly on the dopamine receptors - in tablet form, with other possible forms including injection and a pump.
Permax[R] (pergolide, Eli Lilly) is a dopamine agonist
and was approved by the U.
The condition was connected to dopamine agonist
However, it may be appropriate for doctors to inform patients of this potential risk, particularly in their patients taking relatively high dosages of a dopamine agonist
, and with a documented history of depression or anxiety disorder.
Researchers now report that patients randomly assigned to routinely take the dopamine agonist
ropinirole report fewer side effects than patients getting regular doses of levodopa do.
The report Treatment Algorithms in Parkinson's Disease also finds that UCB's Neupro, a novel, once-daily transdermal dopamine agonist
that was relaunched in the United States for the treatment of PD in July 2012, garnered a total patient share of 3 percent among recently treated patients in Q2 2013, more than doubling over the previous year.
The multivariate analysis also showed that there were significantly higher odds for the presence of impulse control disorders at follow-up among the patients who had a higher dopamine agonist
levodopa-equivalent daily dose at baseline (OR, 2.