Postmortem findings included diffuse alveolar damage
, pleural effusions, and fibrinous pericarditis.
The presence of pancytopenia, diffuse alveolar damage
, severe coagulopathy and neurologic status changes can all be explained on the basis of the hypercytokinemia found in reactive hemophagocytic syndrome.
Histopathologic examination of lung specimens from SARS victims revealed features of diffuse alveolar damage
with marked pulmonary edema and hyaline membrane formation.
For the pathologist, acute exacerbation typically manifests as acute and/or organizing diffuse alveolar damage
superimposed on the background patchy fibrotic pattern of UIP.
18) Acute lung injury patterns, seen in patients with sudden respiratory failure, can assume the form of OP or diffuse alveolar damage
(DAD) (Figure 4).
Postmortem examination revealed bronchopneumonia with diffuse alveolar damage
in the badger and interstitial pneumonia with diffuse alveolar damage
in the binturong.
Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage
Infection with highly pathogenic avian influenza (HPAI) virus (H5N1) leads to severe and often fatal diffuse alveolar damage
and systemic virus spread in cats (3-5).
Second, premature infants deficient in surfactant develop diffuse alveolar damage
early after beginning respiration.
This array of morphologic alterations is known as diffuse alveolar damage
2,3) Subcutaneous silicone injections have led to acute pulmonary dysfunction due to silicone pulmonary emboli, acute pneumonitis, acute pulmonary hemorrhage, diffuse alveolar damage
, acute granulomatous pneumonitis, and lymphadenitis, with subsequent deaths.
Common findings in both patients were diffuse alveolar damage
and positive staining for influenza A virus antigen in alveolar epithelial cells (Figure 1).
The pathologic stages of ALI/ARDS or diffuse alveolar damage
can be divided into 3 subsequent and somewhat overlapping phases: (1) exudative phase, characterized by neutrophilic infiltrate, hemorrhage, and the accumulation of a protein-rich pulmonary edema; (2) fibroproliferative phase, including chronic inflammation, early fibrosis, resorption of hyaline membranes, and neovascularization; and (3) recovery phase, seen in surviving patients.
The autopsy showed proliferative phase of diffuse alveolar damage
, interstitial pneumonia, focal hemorrhage, and bronchiolitis.
Acutely ill patients, particularly those requiring mechanical ventilation, most often will have diffuse alveolar damage