Organization and fibrosis as a response to lung injury in diffuse alveolar damage
, organizing pneumonia and acute fibrinous and organizing pneumonia.
OF PERCENTAGE (%) CASES (n) PULMONARY EDEMA 39 26 DIFFUSE ALVEOLAR DAMAGE
32 21 ACUTE PULMONARY CONGESTION 26 17.
Thus in a peripheral centre like us where the report of PCR was received after the autopsy was conducted, Diffuse alveolar damage
, necrotising bronchopneumonia, bronchitis, peripheral pulmonary thrombus as well as thrombus in large vessels without decrease in platelet count should clinch the diagnosis of Influenza A H1N1.
Postmortem findings included diffuse alveolar damage
, pleural effusions, and fibrinous pericarditis.
There were hyaline membranes and edema, indicative of diffuse alveolar damage
, and the presence of focal hemorrhage in both lungs.
Lung pathology findings in fatal SARS cases were dominated by diffuse alveolar damage
, epithelial cell proliferation, macrophage infiltration in the lung (6-9), and occasionally, features of bronchiolitis obliterans organizing pneumonia (10).
All of the biopsies from the five case-patients in Canada revealed NSIP; two also showed dominant areas of diffuse alveolar damage
, and three revealed lymphoid nodules with germinal centers.
County Coroner's office autopsy report revealed that Corey died of diffuse alveolar damage
and pneumonia, together with hypertrophic cardiomyopathy and coronary arteriosclerosis, ruled a natural death.
Originally used by Katzenstein to encompass diffuse alveolar damage
(DAD) and the entity previously known as bronchiolitis obliterans with organizing pneumonia, now known as organizing pneumonia (OP), the term was meant to reflect the relatively acute onset of both entities as well as the temporal uniformity of both processes.
The most common histopathologic finding was diffuse alveolar damage
comprising intraalveolar edema, hyaline membranes, fibrin, and hemorrhage.
In all cases, histologic examination revealed varying degrees of necrotizing bronchiolitis, diffuse alveolar damage
, and alveolar hemorrhage admixed with pulmonary edema.
Histologic sections showed diffuse alveolar damage
Histopathologic analysis of lung tissue from the two deceased patients indicated diffuse alveolar damage
with microemboli and minimal inflammatory cell infiltrate.
Acute pulmonary injury (APL) is often associated with significant morbidity and mortality, and histologic presentation of diffuse alveolar damage
Pulmonary involvement in cases of leptospirosis is characterized by congestion and hemorrhage, usually without prominent inflammatory infiltrates (4); pulmonary involvement in cases of severe pandemic (H1N1) 2009 typically manifests as diffuse alveolar damage