Hartmann said, "The plasmacytoid
dendritic cells that are activated by CpG oligos appear to have a key role in triggering the development of Th1- type immune responses which are critical for successful immunotherapy of cancer, infections, and allergy.
42, a new monoclonal antibody directed against a fixative-resistant antigen of follicular
dendritic cells.
LEAPS-peptide vaccines and LEAPS-based
dendritic cell vaccines have the potential to provide safe and effective protection and treatment for infectious, oncogenic and autoimmune diseases.
The acetaminophen treated mice with depleted
dendritic cells had more extensive liver cell and tissue death compared to other mice.
In the December 2002 Nature Immunology, they reported that exosomes originally isolated from
dendritic cells, when injected into mice, are captured by other
dendritic cells.
Sarcomatoid tumours of lymph nodes showing follicular
dendritic cell differentiation.
NW Bio is already using these next generation methods for producing more potent
dendritic cells in its production of DCVax-Direct.
First generation
dendritic cell therapies employing
dendritic cells loaded ex-vivo with a single antigen or fusion protein have proven safe and effective in clinical trials for prostate cancer.
This platform is based on optimizing a patient's own (autologous)
dendritic cells to trigger a tumor- or pathogen-specific immune response.
Company Advances Immuno-Oncology Position Using Agents That Stimulate
Dendritic Cells In Vivo
Dendritic cells are antigen presenting cells that display the digested fragments of phagocytosed pathogens to other immune cells.
In their paper published in the open-access journal PLOS Pathogens, the research team reports finding that
dendritic cells of elite controllers are better able to detect the presence of HIV -- paradoxically through a greater susceptibility to HIV infection -- which enables them to stimulate the generation of T cells specifically targeting the virus.
Oncologists have extensively studied the mechanism of
dendritic cell cancer vaccine for several years and they been able to modify them according to medical necessities Loading
dendritic cells with antigens isolated from tumor cell has been used for cancer vaccines for identifying different categories and sub-categories of a given cancer.
Disruption of this activity, the researchers found, allows Ebola to prevent the full development of
dendritic cells that would otherwise trigger an immune response to the virus.
Some of these pieces get on to the membranes of immune cells called
dendritic cells.
