Increased risk for demyelinating diseases
in patients with inflammatory bowel disease.
Multiple sclerosis is a demyelinating disease
of the CNS, which typically takes a relapsing-remitting course.
However, pathology revealed a variety of nonneoplastic etiologies, including demyelinating disease
, vascular disease, inflammation, and infection, as well as posttreatment effects.
In the present study, we observed that a substantial percentage of the samples had a diagnosis of demyelinating diseases
, especially MS, as their diagnostic protocol included the presence of oligoclonal bands of Ig G and/or the index of Ig G in CSF (4).
Other CNS demyelinating diseases
occur as a consequence of infection of the CNS (eg, progressive multifocal leukoencephalopathy, subacute sclerosing panencephalitis, and progr essive rubella panencephalitis).
The new criteria are vital for people at risk for MS and their physicians because they outline procedures to help make a secure MS diagnosis in the face of widely variable clinical symptoms that could be characteristic of a number of inflammatory, demyelinating diseases
, of which MS is one.
In June 1985, BC/BS updated its assessment and recommended that MRI be considered" generally accepted medical practice for diagnostic conditions of the posterior fossa (cerebellum and brainstem) and high (C1 through C4) cervical cord and demyelinating diseases
of the white matter of the brain.
It also reviews key players involved in the therapeutic development for Demyelinating Diseases
Idiopathic inflammatory demyelinating diseases
(IIDDs) constitute a group of disorders characterized by inflammatory lesions, those are associated with loss of myelin and eventually axonal damage.
They discuss the major clinical needs for quantitative biomarkers of the spinal cord, including the rationale for quantitative MRI and clinical applications, inflammatory demyelinating diseases
, and traumatic spinal cord injury; physics, hardware, and technical challenges; imaging methods for various structures (diffusion, magnetization transfer, relaxation, and atrophy measurements); imaging for functional and vascular characterization; and metabolic measurements using magnetic resonance spectroscopy.
Movement disorders in multiple sclerosis and other demyelinating diseases
Sherman's lab has more than 15 years of extensive experience in multiple models of demyelinating diseases
such as multiple sclerosis (MS), and in the application of these models to identify novel therapeutic approaches.
Many other factors can contribute to the problems associated MS and other demyelinating diseases
, he said.
Among them are the cell biology of phagocytosis, mechanism of function and disease of natural and replacement heart valves, the pathology of demyelinating diseases
, the pathogenesis of mixed-lineage leukemia, tuberculosis pathogenesis and immunity, and the pathogenesis of plexiform neurofibroma.
Their process opens a door to research and potential treatments for multiple sclerosis, cerebral palsy and other demyelinating diseases
afflicting millions of people worldwide.