Inovio's delivery technology applies controlled, millisecond electrical pulses to create permeability in the membrane of cells (electroporation), enabling dramatic uptake into the cells of biological material such as a DNA vaccine
In that study, 89% of the subjects who received IL-12 DNA together with the PENNVAX DNA vaccine
delivered with electroporation produced a vaccine specific CD4+ or CD8+ T cell response compared to 67% who received the DNA vaccine
alone without the IL-12 DNA.
The phase I study, which is still ongoing and will involve 30 healthy volunteers in total, is designed to evaluate the immunogenicity and reactogenicity (tolerability) of the novel PowderJect hepatitis B DNA vaccine
in those who failed to achieve protection from current commercial vaccines (non-responders) and those whose protection has waned.
This DNA vaccine
produces the proteins within hours of being injected.
manufacture: scale and quality Ying Cai, Stephen Rodriguez, Henry Hebel
NYSE Amex: INO), a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today that its therapeutic DNA vaccine
for prostate cancer showed remarkable immune responses in monkeys, following similarly strong, antigen-specific and sustainable T cell levels in previously reported data from earlier animal studies.
Health Care System and Stanford University School of Medicine planned to demonstrate the effectiveness of intramuscular gene injections by comparing them with simply dripping a DNA vaccine
solution onto the skin of mice.
The award citation highlighted Inovio's pioneering development of a DNA vaccine
platform using electroporation delivery and its current clinical-stage DNA vaccine
programs for influenza, HIV and cancer.
Sardesai and Weiner emphasizes the progress of electroporation (EP) as the preferred DNA vaccine
After initial vaccination, the two with the standard vaccination showed higher antibody levels than the DNA vaccine
The presentation will highlight the ability of Inovio's SynCon[TM] technology to side-step current "catch-up" strategies for providing protection against influenza by designing and evaluating broadly cross-protective DNA vaccine
candidates against multiple influenza virus sub-types.
The SynCon(TM) DNA vaccine
evaluated in this study was generated by the creation of PSA and PSMA synthetic consensus immunogens based on human and macaque sequences, which enabled the amino acid sequences of the antigens to differ slightly from the native protein.
flexneri into an oral DNA vaccine
, researchers must first make it safe for humans.
SAN DIEGO -- Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine
design, development and delivery, has unveiled its new CELLECTRA[R]-SP series of hand-held, cordless electroporation devices at the DNA Vaccines
2010 conference being held in New Orleans, LA.
Consequently, this DNA vaccine
should generate antibodies to the AIDS virus and activate immune cells that kill the virus.