com) is a global biotechnology company specializing in high sensitivity genetic variation and mutation analysis, providing products and services in DNA mutation
detection and discovery for clinical research, clinical molecular diagnostics and pharmacogenomics analyses.
These errors end up as DNA mutations
in plants and thus may contribute to plant evolution.
Furthermore, it can be coupled with Transgenomic's proprietary DNA mutation
detection technologies to further improve its sensitivity.
Given prior evidence that mitochondrial DNA mutations
may be associated with cancer, this work provides evidence that Transgenomic's technologies provide the basis for a viable approach to identification of mitochondrial DNA biomarkers that may aid in the early detection and monitoring of various cancers.
Kan s early studies were the first to establish that a single DNA mutation
could result in a human disease, and he was the first to diagnose a human disease using DNA.
In the case of cancer, I believe that the cells' mitochondrial and cytoplasmic health are the primary common-denominator defect which leads to downstream DNA mutations
Individual neurons within a person's skull harbor over 1,000 distinct DNA mutations
, scientists report in the Oct.
The tests analyze the presence of 96 frequently occurring DNA mutations
in nine cancer genes.
In a survey of 92 women who were known carriers of a mitochondrial DNA mutation
or were at risk of carrying a mutation, there was universal concern about transmitting mitochondrial DNA mutations
to their children, and "overwhelming support and widespread interest" in the clinical use of MRT, particularly among women considering having children at the time of the survey, according to Dr.
This will help women carrying DNA mutations
to have healthy babies.
All are at risk of transmitting harmful DNA mutations
in the mitochondria, tiny rod-like power plants in cells, on to their children and future generations.
THAT two in every three cancers are judged to be DNA mutations
doesn't mean we should lead unhealthy lives.
-- long known to fuel cancer as well as evolutionary changes in a living organism -- had been thought to be rare events that occur randomly throughout the genome.
However, the identification of a mutation does not always equate to malignancy or even a precursor lesion, because DNA mutations
are known to occur in benign settings or have no clinical relevance.
Using advanced DNA sequencing technologies, the team from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, led by Professors Teh Bin Tean, See-Tong Pang, Patrick Tan and Steve Rozen discovered that is the most potent carcinogen identified to date, causing more DNA mutations
than cigarette smoke or ultraviolent light.