The clinical presentation of FHL includes primarily fever, hepatomegaly, and cytopenia, which are the results of functional degradation in cytotoxic T-lymphocytes
and natural killer (NK)-cells, activation of macrophages and T-lymphocytes, excessive production of proinflammatory cytokines, and hemophagocytosis (1-3).
As with survivin overexpression (5-7), livin overexpression by cancer cells may lead to anti-livin antibody responses and cytotoxic T-lymphocyte
responses against the cancer.
T cells, secretory immunoglobulin A (S-IgA), and antigen-specific cytotoxic T-lymphocytes
For this reason, many researchers are trying to create vaccines that stimulate cytotoxic T-lymphocytes
(CTLs), immune-system cells that kill virus-infected cells in the body.
Cell-mediated immunity is an immune response that does not involve antibodies but rather involves the activation of macrophages, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes
, and the release of various cytokines in response to an antigen.
Plasmacytoid dendritic cells when stimulated produce large amounts of chemical messengers, such as interferon-alpha, that promote a Th-1 response, resulting in production of cytotoxic T-lymphocytes
that can directly attack foreign agents.
Recently, her research group studied how TCDD affects a mouse's production of cytotoxic T-lymphocytes
, which destroy cells infected with viral invaders.
More importantly, the two peptides were found to be readily recognized by cytotoxic T-lymphocytes
derived from mice expressing the human HLA-B*0702 proteins demonstrating that consistently presented peptides derived from intracellular proteins are recognized by the mammalian immune system.
cell therapy process inhibited cytotoxic T-lymphocytes
by 93% and