Also, POLE-mutants had an increased density of cytotoxic T-cells
(CD8+) at the tumor center and margin that significantly exceeded that of POLE wild-type or MSS tumors.
Although the exact mechanism is still not well established, a number of investigations have suggested that intraoperative blood transfusion could weaken the function of host natural killer cells, cytotoxic T-cells
, macrophages, and monocytes and increase the number of suppressor T-cells.
10 A hallmark of HLH is impaired or absent function of natural killer cells and cytotoxic T-cells
It increases the number of tumour-infiltrating cytotoxic T-cells
and dendritic cells.
Melan-A is an antigen recognized by cytotoxic T-cells
initially thought to be restricted to melanocytic tumors, but later on recognized to be present on steroid hormone-producing neoplasms including adrenocortical tumors (2).
In addition to the demonstrated ability of Dynavax's vaccine to generate cytotoxic T-cells
and cytotoxic antibodies, the data showed that the universal components of Dynavax's vaccine enhance the efficacy of a standard flu vaccine by increasing antibody production directed at virus neutralization, the company said.
Impaired function of natural killer (NK) and cytotoxic T-cells
In the thymus, the T lymphocytes gain further specificity, forming either helper T-cells (CD4) or cytotoxic T-cells
An ultrastructural study of cutaneous panniculitis-like T-cell lymphoma: cytoplasmic granules and active cellular and cell-to-matrix interaction mimic cytotoxic T-cells
Two measures of response were used in this paper: stimulation index, a measure of so-called 'cell-mediated immunity' (CD4 responses), and [gamma]-interferon enzyme-linked immunosorbent spot (ELISPOT), which demonstrates the presence and frequency of [gamma]-interferon-secreting cells, a marker for the presence of cytotoxic T-cells
T-cells develop in the thymus, which shrinks in size as people age; they are divided into cytotoxic T-cells
and helper T-cells.