Gajewski said that the vaccines most likely to succeed are those developed through a stepwise scientific approach, which involves methodical selection of antigens in combination with the adjuvants that produce the optimal cytotoxic T-cell
Increased tumor cell death and decreased tumor burden by decreasing macrophage and increasing cytotoxic T-cell
infiltration in preclinical studies of malignant mesothelioma, conducted by collaborators led by Dr.
Xencor's initial bispecific programs are tumor-targeted antibodies that contain both a tumor antigen binding domain and a cytotoxic T-cell
binding domain (CD3 binding domain).
Hydroa Vacciniforme-like Lymphoma: Cytotoxic T-cell
or less often [CD56.
He added: "Activation of Toll receptors was essential for two key stages in initiating immune responses against the tumor - the migration of peripheral dendritic cells into the brain tumor and the subsequent activation of dendritic cells and stimulation of a specific anti-tumor cytotoxic T-cell
Human cytotoxic T-cell
memory: long-lived responses to vaccinia virus.
Investigators suspect that rhIL-12 enhances cell-mediated immunity by inducing interferon-[gamma] production and by augmenting natural killer cell cytotoxicity and cytotoxic T-cell
proliferation and function.
The M2e/NP-ISS is expected to enable subjects to generate cytotoxic cross-protective antibodies and cytotoxic T-cell
protection, while the trivalent influenza vaccine offers strain-specific neutralizing antibodies.
Subcutaneous panniculitis-like T-cell lymphoma is a rare cytotoxic T-cell
lymphoma that can be misdiagnosed as a benign panniculitis due to histologic similarities between the 2 entities.
When administered as a therapeutic, the bispecific immune cell engager brings cytotoxic T-cells
in contact with the target cancer cell where the cytotoxic T-cell
kills the cancer cell.
The clinical significance of this difference is unclear at this time, but it appears that our case represents a more mature stage showing cytotoxic T-cell
We applied a bioinformatics (EpiMatrix) approach to search the WN virus NY99 genome for HLA B*07 restricted cytotoxic T-cell
LAMP-vax DNA plasmids show no decrease in CD8+ cytotoxic T-cell
response, yet also feature a CD4+ response.
Natural killer cell activity is defective, causing impaired cytolysis of tumors and virally infected cells; cytotoxic T-cell
responses against allogeneic tumor cells are also abnormal (70,71).
Xencor's initial bispecific programs are tumor-targeted antibodies that contain both a tumor antigen binding domain (CD123, CD20, or CD38) and a cytotoxic T-cell
binding domain (CD3).