Cytotoxic T lymphocyte
antigen-4 (CTLA-4) A49G polymorphism and auto-immune blood diseases, Turk J Hematol.
The most important effectors of the cell-mediated immune response, cytotoxic T lymphocytes
, are the main immune cells that recognize foreign antigens on the surface of infected "self" cells.
Measurement of donor-specific cytotoxic T lymphocytes
can identify patients in whom immunosuppressive medications can be safely reduced, according to a report in the July 15 issue of Transplantation.
When combined with disease-specific antigens, the technology creates JuvaVax(TM) vaccines capable of activating substantial antibody- and cell-mediated immune responses, particularly induction of cytotoxic T lymphocytes
Tat-specific cytotoxic T lymphocytes
select for SIV escape variants during resolution of primary viraemia.
Key words: Cytotoxic T lymphocyte
antigen-4 (CTLA-4), A49G polymorphism, autoimmunity, idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, chronic lymphocytic leukemia
Primary induction of human CD8+ cytotoxic T lymphocytes
and interferon-gamma-producing T cells after smallpox vaccination.
The enhancement of T helper activation probably augments cytotoxic T lymphocyte
activity by stimulating dendritic cells.
A more recent paper by this same group of researchers and colleagues in San Francisco and Seattle (3) found that although patients treated during PHI had less diverse viral populations, they also had weaker and narrower cytotoxic T lymphocyte
(CTL) responses than patients treated with antiretroviral therapy soon after seroconversion.
Long-lived cytotoxic T lymphocyte
memory in mucosal tissues after mucosal but not systemic immunization.
The study demonstrates that MUC-1 in the form of an immune complex is more efficiently processed than MUC-1 alone, leading to T helper cell stimulation and an enhanced cytotoxic T lymphocyte
HSV specific cytotoxic T lymphocyte
(CTL) responses were induced in
Nasdaq: VIGN) reported yesterday that an interim evaluation of its directly injected gene therapy product for HIV infection, HIV-IT (V), supported a product- related enhancement of HIV-specific cytotoxic T lymphocyte
(CTL) activity in subjects infected with HIV-1.
Patent and Trademark Office regarding the issuance of a patent relating to its Targeted Cytotoxic T Lymphocyte
(CTL) platform technology.
Targeted Genetics is currently evaluating the IL-2 gene in its cytotoxic T lymphocyte
(CTL) based immunotherapy program for HIV and cytomegalovirus (CMV) infection.