Th researchers say the CNTs' topography boosts interactions between cells and long-term cultures, offering a fast and effective stimulation of the cytotoxic T cells
that are key to eradicate cancer.
Specifically, the investigators examined the NK cell cytoskeleton (the part of each cell primarily responsible for the spatial organization of its components) during target cell killing in comparison to that of cytotoxic T cells
of Northwestern University, and Targeted Genetics used the immune system, specifically cytotoxic T cells
, to destroy HIV-infected cells.
The researchers were working at the John Curtin School of Medical Research in Canberra, Australia, in the early 1970s when they began to study how genetic variability influences the response of cytotoxic T cells
The demonstration that infused cytotoxic T cells
can migrate to lymph nodes, the major site of HIV-1 replication, and that this is associated with greater cytotoxic activity against HIV-1 in the lymph nodes provide hope that this form of therapy may provide benefit to HIV-1 infected persons.
It gives us a little more information on how cytotoxic T cells
can contribute to defense by causing cells themselves to become more resistant," agrees Barry T.
Paterson has found ways to modify the presentation of antigen by Listeria constructs to the immune system, that Listeria vaccines exert an extremely powerful stimulatory direct effect upon the generation of tumor killing cytotoxic T cells
in ways that result in therapeutic responses not seen heretofore," Dr.
Using specific antibodies, they looked for three major types of immune cells: cytotoxic T cells
, helper T cells and dendritic cells as well as tumor cells.
The poster presentation, "Defibrotide and Oligotide, Two DNA-Based Drugs, Protect Human Microvascular Endothelial Cells Against Chemotherapy-Induced Damage and Activation," reports that data showed the drugs' potential ability to protect human endothelial cells from chemotherapy-induced activation, transendothelial migration and apoptotic damage and may eliminate the increased allogenicity of cytotoxic T cells