To achieve a mechanistic understanding of how cell organization is regulated, we will develop methods to manipulate cytoskeletal
interactions in space and time and study the effects of such manipulation on functional cytoskeletal
organization in the confinement of both artificial systems and cells.
Through interaction with vascular endothelial cell cytoskeletal
proteins, ZYBRESTAT selectively targets and collapses tumor vasculature, thereby depriving the tumor of oxygen and causing death of tumor cells.
Recent progress in the study of cancer cell motility and invasion has generated greater understanding of the mechanical properties involved in malignant transformation and cell mechanics, which have emerged as important markers for cytoskeletal
organization, cell adhesion, and spreading.
ROCK is an enzyme that phosphorylates cytoskeletal
regulatory proteins and plays a role in cytoskeletal
However, each protein influenced the function of a different cytoskeletal
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal
reorganization of non-muscle cells.
network along the edge of the infected cells was enhanced and could be involved in transporting and expelling the progeny virus particles.
Up to now, it has not been appreciated that cytoskeletal
organization is an important element in the regulation of NK cell activity," Wuelfing emphasizes.
The water-swellable polyelectrolyte acts as a support for the biomembrane, not unlike the cytoskeletal
support found in mammalian cell membranes.
To confirm the likely diagnosis of leiomyosarcoma, immunohistochemistry was performed for cytoskeletal
proteins such as actin, myosin, and desmin; these proteins have been widely used in the differential diagnosis of sarcomas.
Cells treated with IGF-1, mechanical stretch, or a combination of both were tested through parameters of cell organization, cytoskeletal
organization, collagen expression, collagenase expression, cell proliferation, and signal transduction using Pierce Assays, Western Blots, and confocal microscopy.
system serves as a structural framework that surrounds and supports the contractile apparatus in the body of the cell and has 3 major domains, which have several protein components.
In the present study initial attachment characteristics were assessed by Scanning Electron microscopy, cytoskeletal
organization by actin staining and focal contact by vinculin staining followed by fluorescence microscopy, enabling to examine microfilaments and focal contacts.
The thirteen titles carry fully descriptive titles; Composition and structure; Muscle cell differentiation and growth; Proteins of thick filament; Proteins of the thin filament - actin, tropomyosin and troponin; Cytoskeletal
and other proteins of the myofibrils; Sacroplasmic reticulum; Contraction and rigor mortis; Skeletal muscle growth and protein metabolism; Skeletal muscle fibre types; Cardiac and smooth muscle; Sacroplasmic proteins; The connective tissues - collagen, elastin and ground substance; and Postmortem changes during conversion of muscle to meat.
The mechanics of these simple tissues is dictated by the cytoskeletal
and adhesive proteins that interface the constituent cells into a tissue-scale mechanical syncitium.