are believed to be the primary cause of death in young and otherwise healthy people who are infected with influenza, particularly pandemic flu strains.
Nikolai Schwabe, CEO of ProImmune, said "First infusion cytokine storm
reactions to new therapeutics can represent a substantial stumbling block to drug development.
It now rests with the government to periodically inform the public the actual diagnoses of those who die with a positive result on H1N1 test--how many died of co-morbidities, how many due to [neglected] secondary bacterial pneumonia and how many directly due to influenza virus-induced cytokine storm
Search for therapeutic vaccines (anti-disease vaccines) aimed at controlling innate immune responses should be pursued, given the clinical evidence that the H5N1 subtype elicits a cytokine storm
that contributes to disease pathogenesis.
An influenza virus that causes a cytokine storm
would kill not just those with the weakest immune systems, but those with the strongest as well.
can result in autoimmune reactions, tissue damage, or septic shock.
ImmunoSIGNAL([TM]) Cytokine Storm
Cellular Assay is a unique proprietary in vitro assay that evaluates biologics for their potential to induce cytokine storm
If there were a cytokine storm
(as in the severe flu virus of 1918), where the immune system attacks not only the virus but damages internal organs and tissue, pregnant women and 15-to-40 year olds would suffer the highest case fatality rate.
A cytokine storm
is a dysfunctional innate immune response involving unchecked production of pro-inflammatory mediators.
Research studies and review articles published in the journal Viral Immunology reveal that a cytokine storm
occurs when the body's immune system over-reacts to an intruder, such as a virus, by producing high levels of cytokines.
Barton, PhD Immunologist, CSO of the Company, adding, "This indicates that FluCide drug candidates may be highly effective in severe cases of influenza as well as cases of bird flu, H5N1, by protecting the patient from cytokine storm
Researchers believe the virulence associated with the 1918 virus was triggered by an overreaction of the immune system, known as a cytokine storm
Unfortunately, antiviral drugs are unable to shut off a cytokine storm
once it has been triggered.