In this 3 year follow up of the DASISION study, the median time to response (Complete Cytogenic
Response, or CCYR) for dasatinib was 3.
Project's full title: "A Cytogenic
Analysis of Genetic Mutation Induced by Cigarette Smoke in Drosophila Melanogaster"
analysis of lymphocytes from workers in a nickel refinery.
and survival adaptive responses in G-1 phase human lymphocytes.
blood cell counts returned to normal)(1); Furthermore 40% of patients achieved a complete cytogenic
response(1) (meaning that no abnormal chromosomes, the root cause of CML, are detected in the bone marrow cells)(1).
method of cancer diagnosis.
and fluorescence in situ hybridization (FISH) studies help establish evidence of abnormal clones, classify the disease, and assist with prognosis.
testing detects changes in chromosomal number or structure (which could indicate, for instance, Down syndrome); biochemical genetic testing measures proteins and metabolites (which could signal, for example, phenylketonuria, or PKU); molecular genetic testing uses nucleic acid probes to identify alterations in DNA sequences that can predict early-onset diseases such as CF and late-onset illnesses such as Huntington's disease.
Fifty-three percent of patients in this series had a complete cytogenic
response, defined as absence of Philadelphia chromosome by fluorescence in situ hybridization (86).
Children with unexplained mental retardation should undergo genetic screening with comparative genomic hybridization when standard cytogenic
techniques fail to detect chromosomal abnormalities, according to Dr.
Comparative genomic hybridization (CGH) is a molecular cytogenic
technique that enables simultaneous enumeration of every chromosome, in contrast to fluorescent in situ hybridization (FISH), which at present can karyotype only a maximum of nine chromosomes, Leeanda Wilton, Ph.
population parameters, capture-mark-recapture studies, physiological and behavioral characters, morphometric and meristic characters, calcareous characters, cytogenic
characters, and biochemical characters; Ihssen et al.
41% of these patients demonstrated a cytogenic
response--that is, their chromosomes returned to normal.
and molecular analysis of an aggressive angiomyxoma.
It is recommended to perform morphologic and cytogenic
bone marrow examinations approximately every 12 months in patients with severe chronic neutropenia.