The cytochrome P450
monooxygenase system is more affected by aging than any other metabolic pathway (3).
The company's approach, based on a proprietary technology platform, uniquely enables the design of multiple classes of anticancer prodrugs that are selectively activated by extra-hepatic cytochrome P450
enzymes that are greatly over-expressed in a broad range of solid tumor and hematologic cancers, but not in normal tissues.
Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome P450
Jasmonate and salicylate induce expression of herbivore cytochrome P450
Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450
3A subfamily enzymes.
The resulting WIF-B cell line expressed both alcohol dehydrogenase and cytochrome P450
2E1, maintained polarity, and formed functional bile canaliculi (Shanks et al.
Inventors: Williams, PA,; Cosme, JM,; Ward, A; Brewerton, SC; Hamilton, BJ,; Jhoti, H; Jones, MA,; Vuillard, L, Michel, M; Williams, MG; "Crystals of Cytochrome P450
2C9, Structures Thereof and Their Use.
Dentists already know about cytochrome P450
2D6, because just this year Roche Diagnostics received approval for its AmpliChip CYP450 test, a microarray test for clinical use.
The cytochrome P450
aromatase was purified from equine microsomes, after its separation from reductase, by successive chromatographic steps: concanavalin A-Sepharose 4B affinity column, diethyl amino ethyl-Sepharose CL-6B ion exchange, and hydroxyapatite-Sepharose 4B adsorption/partition columns (Moslemi et al.
John's wort contains two compounds--hypericin and hyperforin--that induce cytochrome P450
to increase the rate of drug metabolism.
Alternatively, since clozapine is also metabolized by the 1A2 isoenzyme of cytochrome P450
, some kind of competitive inhibition may have been involved.
Kaletra is metabolized in the liver by cytochrome P450
, almost wholly by the CYP3A isoform.
Enzyme Inhibition and Inactivation: Cytochrome P450
The in vitro induction potential of the extracts was tested in freshly isolated human hepatocytes from 3 donors as influence on the catalytic activity of five cytochrome P450
isoenzymes, namely 1A2, 2B6, 2C9, 2E1, and 3A4 on the respective marker substrates.
The joint research group has elucidated that cytochrome P450
oxidase, a protein expressed in eui genes, suppresses the activity of gibberellin.