Cabergoline therapy for Cushing disease
Exaggerated increases in ACTH concentrations after CRH administration are indicative of Cushing disease
They cover pituitary cell development and organization in adults, genetics, research topics, therapies, tumorigenesis, prolactinomas, growth hormone and acromegaly, the role of estrogens in the remodeling of the anterior pituitary gland, alcohol-induced hyperprolactinemia, gender differences in tumors, carcinomas, testing growth hormone deficiency in adults, imaging, the hypothalamic-pituitary-adrenal axis, Cushing disease
, and other topics.
Characteristically ectopic ACTH production is said to cause a clinical syndrome which, unlike pituitary dependent Cushing disease
is of rapid onset associated with rapid weight loss, muscle weakness, hypokalemic metabolic alkalosis, glucose intolerance, high levels of plasma cortisol and ACTH.
His name is known to every medical student and is immortalized in the well-known Cushing syndrome, Cushing disease
, Cushing reflex, and Cushing ulcer.
First-line treatment for Cushing disease
is surgical removal of the adrenocorticotrophin-secreting pituitary tumor.
Topics include the role pituitary tropic status has in tumor development, the estrous cycle as an instigator of anterior pituitary cell renewal, bone morphogenetic Protein-4 control of pituitary pathophysiology, and an animal model of prolactinoma, estrogen-treated animals to use in studies, the question of whether dopamine agonist treatment should be life-long, pituitary differentiation and regulation and the implications in hormone research, the regulation of growth hormone sensitivity by sex steroid, gene therapy in the neuroendocrine system, expression of somatostatin receptor subtypes and treatment outcomes, and new aspects in the diagnosis and treatment of Cushing Disease
In patients with confirmed Cushing disease
and severe renal impairment, the urinary free cortisol excretion rate reportedly is normal despite markedly increased plasma cortisol (4-6).