Exaggerated increases in ACTH concentrations after CRH administration are indicative of Cushing disease
These tumors, either through direct release or through production of precursors, preferentially express the proopiomelanocortin gene, which leads to the release of markedly higher ACTH concentrations in comparison to typical Cushing disease
His name is known to every medical student and is immortalized in the well-known Cushing syndrome, Cushing disease
, Cushing reflex, and Cushing ulcer.
The winners are Teva's Copaxone, a specialty drug for the treatment of chronic disease (in this case MS), and Corcept's KORLYM, an orphan drug for Cushing Disease
, a rare condition -two most popular categories of biopharmaceutical R&D activity.
Investigators rapidly excluded 2 well-known conditions associated with increased ACTH concentrations: Cushing disease
(ACTH-producing pituitarytumor) and Addison disease (adrenal insufficiency) (1, 2).
Topics include the role pituitary tropic status has in tumor development, the estrous cycle as an instigator of anterior pituitary cell renewal, bone morphogenetic Protein-4 control of pituitary pathophysiology, and an animal model of prolactinoma, estrogen-treated animals to use in studies, the question of whether dopamine agonist treatment should be life-long, pituitary differentiation and regulation and the implications in hormone research, the regulation of growth hormone sensitivity by sex steroid, gene therapy in the neuroendocrine system, expression of somatostatin receptor subtypes and treatment outcomes, and new aspects in the diagnosis and treatment of Cushing Disease
The winners include Teva's Copaxone, a specialty drug for the treatment of chronic disease (in this case MS), and Corcept's KORLYM, an orphan drug for Cushing Disease
, a rare condition -the two most popular categories of biopharmaceutical R&D activity for one obvious reason-optimal return on investment.
First-line treatment for Cushing disease
is surgical removal of the adrenocorticotrophin-secreting pituitary tumor.
In patients with confirmed Cushing disease
and severe renal impairment, the urinary free cortisol excretion rate reportedly is normal despite markedly increased plasma cortisol (4-6).