Cox-2 inhibitor

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  • noun

Words related to Cox-2 inhibitor

an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1

References in periodicals archive ?
This reassures readers that the observational study design is as robust as possible, and that treatment effects alone account for the observed differences among opioid, NSAID, and coxib users.
Cardiovascular adverse events -- including myocardial infarction, stroke, new or worsening of pre-existing arterial hypertension, congestive heart failure, and several less severe CV events -- were monitored and retrospectively related to the use of coxibs, tNSAIDs and glucocorticoids.
5] Nonstandard abbreviations: coxib, cyclooxygenase-2 inhibitor; tNSAID, traditional nonsteroidal antiinflammatory drug; BNP, B-type natriuretic peptide; NT-proBNP, N-terminal proBNP; N-AE, cardiovascular adverse event; OA, osteoarthritis.
But Scarpa notes some promising preliminary research in preemptive coxib ingestion (before surgery) to curtail swelling and pain afterward.
Analgesic Exposure: Exposure was categorized based on analgesic class: coxib, opioid, or nonselective NSAID.
Guidelines recommend concomitant use of a PPI with traditional NSAIDs or a coxib in patients at risk of GI effects.
and Europe, support a significant limitation of our use of not only the coxibs but the entire NSAID class.
And as a member of the coxib class of NSAIDs, the drug appears to have a very good safety profile for everyday, long-term use in healthy dogs.
Also included in other promoted medicines were global sales of Merck's coxib, ARCOXIA, which reached $57 million in the first quarter, compared with $30 million in the first quarter of 2004.
In addition to the withdrawals of rofecoxib and valdecoxib, the benefit/risk ratio of the remaining selective COX-2 inhibitors has been reassessed recently in such a way that the use of a conventional NSAID alone or combined with a gastroprotective agent appears to be preferable to that of a coxib," he wrote.
Developed by Pharmacia Corporation in the United States, celecoxib is the first coxib anti-inflammatory agent to interfere with the production of prostaglandin and other chemicals involved in inflammation by selectively inhibiting COX (cyclooxygenase)-2 enzyme.
Merck is working with the European Medicines Agency to assess whether changes to the prescribing information for the coxib class of drugs, including ARCOXIA, are warranted.
Prescribe a coxib or aspirin prophylaxis an NSAID and a PPI.
Global sales of Merck's coxib, ARCOXIA, reached $61 million in the third quarter and $153 million for the first nine months.