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This led to the testing of COX2 inhibitors in the chemoprevention of colorectal cancers, in which a protective action was demonstrated.
Clinical data seem to suggest activity for at least some agents that merit further investigation--these include vitamin A, vitamin C, megadose vitamins and COX2 inhibitors.
NSAIDs, especially COX2 inhibitors, block the COX pathway inhibiting prostaglandin synthesis.
Current therapeutic drug options for osteoarthritis are used to reduce osteoarthritis symptoms, mainly pain and inflammation, but are limited to analgesics, COX2 inhibitors, NSAIDS and intra-articular corticosteroid injections.
Because the evidence of GI benefit from COX2 inhibitors initially seemed to outweigh evidence of CV risk, the Food and Drug Administration (FDA) first pursued its policy of cautiously labeling celecoxib and rofecoxib in ways that reflected the outcomes of the CLASS and VIGOR studies.
Patients, particularly community-dwelling elderly patients, will be curious of the cost of cox2 inhibitors.
There are reasons to hope that the COX2 inhibitors may stop premature labor, have anti-cancer effects, and prevent the progression of Alzheimer's disease.