The world seems to have become settled in the belief, long ago, that it is not possible for human genius to outdo this creation of da
Eu Jose da Silvestra que estou morrendo de fome na pequena cova
onde nao ha neve ao lado norte do bico mais ao sul das duas
camaras do thesouro de Salomao a traz da morte branca, mas pela
Da Souza had made a fortune trading fiery rum on the Congo and had probably done more to debauch the niggers he spoke of so bitterly than any man in Africa.
Then why," Da Souza asked, looking up with twinkling eyes, "do you want to sell me a share in it?
I will give you four thousand pounds for a quarter share," Da Souza said.
Toward the end of the fifteenth century the Portuguese sailor, Vasco da
Gama, finishing the work of Diaz, discovered the sea route to India around the Cape of Good Hope.
Although COX-2 selectivity
is a likely contributor to the higher CV risk seen with NSAID use, it is not the only factor, given that a higher CV risk has been seen with both coxibs as well as tNSAIDs.
It's well-known that COX-2 selectivity
is generated by one amino acid substitution of isoleucine at position 523 in COX-1 with valine in COX-2, while the smaller Val523 residue in COX-2 opens up an 17% extra space, namely side pocket in the enzyme, which allows large molecules to pass into the entrance of COX-2 channel (Gierse et al.