The nonsignificant difference in complicated upper GI events "is probably the most bothersome thing about the study," because etoricoxib is supposed to be GI-protective and has even more COX-2 selectivity
than some other COX-2 selective NSAIDs, such as rofecoxib, Dr.
Those with greater COX-2 selectivity
are safer from a GI standpoint, and for patients with GI risks, a proton pump inhibitor (PPI) can be given as cotherapy.
With regard to GI risk, the agents listed here possess modest COX-2 selectivity
and are associated with greater GI safety than other prescription- strength nonselective NSAIDs.
The report also evaluates Novartis' Prexige which is of particular interest since its structure is novel and also because it offers the greatest COX-2 selectivity
of all COX-2 inhibitors that have entered advanced stages of development.
Abramson, chairman of rheumatology at the Hospital for Joint Diseases, New York, said that the GI safety data on rofecoxib are "clearly suggestive and consistent" with the hypothesis regarding COX-2 selectivity