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It is suggested that elderly people mount an inadequate response to the insulin resistance of critical illness, which is produced by the actions of increased counterregulatory hormones and cytokines (McCowen et al.
Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers.
Regulation of counterregulatory hormone secretion in man during exercise and hypoglycemia.
Also, algorithms linking the sensor with the delivery system must account for other physiologic factors that contribute to glucose homeostasis, such as incretins, free fatty acids, and counterregulatory hormones.
Anaerobic exercise, such as sprinting, involves the release of counterregulatory hormones (cortisol and epinephrine) that can sharply increase glucose release from the liver.