Effects of environmental and pharmacological stressors on c-fos and corticotropin-releasing factor
mRNA in rat brain: Relationship to the reinstatement of alcohol seeking.
Expression of urocortin and corticotropin-releasing factor
receptor subtypes in the human heart.
Corticosterone induced changes in hypothalamic corticotropin-releasing factor
(CRF) content after stress.
Increased ethanol self-administration and anxiety-like behavior during acute withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor
These results demonstrate that CRF-induced inhibition of gastric emptying can be antagonized by the EO, that is, the EO improves restraint stress-induced inhibition of gastric emptying mainly via central corticotropin-releasing factor
The role of corticotropin-releasing factor
in stress-induced relapse to alcohol seeking', Psychopharm.
Dissection of hypothalamic-pituitary-adrenal axis pathology in 1month-abstinent alcohol-dependent men, part 2: Response to ovine corticotropin-releasing factor
Catecholaminergic modulation of corticotropin-releasing factor
and adrenocorticotropin secretion.
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8(1-ethylpropyl)- 2,6-dimethyl-imidazo [1,2-b] pyridazine: A novel brain-penetrant, orally available corticotropin-releasing factor
receptor 1 antagonist with efficacy in animal models of alcoholism.
Human placenta, chorion, amnion and decidua express different variants of corticotropin-releasing factor
receptor messenger RNA.
Researchers are focusing on the hypothalamus because it releases more corticotropin-releasing factor
when threatened, causing the HPA axis to rev up quickly under stress as part of the "fight or flight response," he explained.
During withdrawal, the rats displayed sharp rises in the concentration of corticotropin-releasing factor
, a chemical released in greater quantities from a particular brain structure in times of stress.
Key Topics Covered: Executive Summary Strategic Considerations Stakeholder Implications Introduction Overview of Panic Disorder Disease Description Diagnosis Pathophysiology of Panic Disorder Norepinephrine Serotonin Gamma-Aminobutyric Acid Glutamate Corticotropin-Releasing Factor
Substance P Prevalence of Panic Disorder Current Therapies for Panic Disorder Selective Serotonin Reuptake Inhibitors Serotonin and Norepinephrine Reuptake Inhibitors Benzodiazepines Emerging Therapies for Panic Disorder Sepracor's SEP-225441 Alexza Pharmaceuticals' AZ-002 Panic Disorder Market: 2007 Statistics and Future Outlook
Another pathway that also has been implicated in alcohol abuse, and particularly in the transition to alcohol dependence, involves two stress-response systems, the hypothalamic-pituitary-adrenal (HPA) axis and the extra-hypothalamic corticotropin-releasing factor
(CRF) stress response system, which mediate the interaction of psychosocial stress and early alcohol use.
In previous animal studies, Roberto and her colleagues demonstrated that a particular stress peptide produced in the amygdala, corticotropin-releasing factor
(CRF), plays a key role in the transition from alcohol use to alcohol dependence.