We postulated that patients whose corneocytes
fail to separate probably lack some substance that destroys the attachments that bind individual corneocytes
to each other, thereby maintaining the integrity of the superficial keratin layer.
constitute the physical barrier of the SC due to their direct contact with environmental factors.
In the follow-up research, two years later, no significant difference was noted in high frequency conductance or capacitance in the youngest age group, although transepidermal water loss values tended to increase with a significant decrease in the size of corneocytes
overproduction of corneocytes
at the entrance of sebaceous follicle ducts
Topical retinoids reverse abnormal desquamation of follicular corneocytes
, inhibit the microcomedones that are the precursor lesions in acne, clear mature comedones, and enhance skin penetration of other medications, most importantly topical antimicrobials.
But its key secret is the retention of large amounts of water inside specially adapted skin cells called foetal corneocytes
Bathing or showering cleans the skin by mechanical removal of bacteria shed on corneocytes
In human stratum corneum of the skin, protein-enriched corneocytes
are embedded in a lipid-rich matrix that impedes egress of water and penetration of pathogenic microorganisms, allergens, and noxious chemicals.
Other targets are the projected size of the corneocytes
or the thickness of the stratum corneum.
LHA offers precise, cell-by-cell exfoliation proven to exfoliate six times more the number of corneocytes
than salicylic acid(2).
Furthermore, mild swelling of corneocytes
was also observed in the studies, suggesting retention of fluids and thus providing an insight into the sustained drug-delivery mechanism of ethosomes.
The superficial skin layers contain water to keep the skin soft and pliable and lipids to prevent dehydration of the corneocytes