The proteins of HBV collectively known as hepatitis B surface antigen (HBsAg) and hepatitis B core antigen
(HBcAg) are important markers for the diagnosis of infection (Krajden et al.
Prevention of Post-Transfusion Hepatitis by Screening of Antibody to Hepatitis B Core Antigen
in Healthy Blood Donors.
Strong correlation between liver and serum levels of hepatitis C virus core antigen
and RNA in chronically infected patients.
1) 0 Anti-HBs--antibody to hepatitis B surface antigen, anti-HBc--antibody to hepatitis B core antigen
1 Pal et al8 found that while core and NS3 antigens are equally associated with HCV infection, NS3 antigen is more closely associated with HCV replication than is core antigen
The first indirect marker, IgM antibody to the nucleocapsid or core antigen
(HBcIM), develops approximately 2 weeks after the appearance of HBsAg, and disappears some 24 weeks later, being gradually replaced by IgG antibodies to the core (Fig.
It is possible that, donors with occult HBV infection, who lack detectable HBsAg might have exposure to HBV infection indicated by positive anti-HBc positive for antibodies against HBV core antigen
and HBV DNA, are a potential source of HBV infection (3).
Antibodies to the above antigens first appear as IgM antibody to the core antigen
Hepatitis B Virus DNA in blood samples positive for antibodies to core antigen
and negative for surface antigen.
Micronesian adolescents who had received three doses of recombinant hepatitis B vaccine (at birth, 2 months, and 6 months of age) and who had tested negative for antibody to hepatitis B core antigen
(anti-HBc) 2 years after the primary vaccination were followed for 15 years after the primary vaccination.
Unsatisfactory specificities and sensitivities of six enzyme immunoassays for antibodies to hepatitis B core antigen
Acute hepatitis B is diagnosed by detection of IgM antibodies to the hepatitis B core antigen
infectious) antiHBs (antibody to * appears as HBsAg disappears or HBsAg): as the only marker after immunization antiHBc (antibody to * appears at the onset of illness core antigen
): and persists indefinitely antiHBc IgM (antibody * appears in high titre during to core antigen
, IgM acute infection and usually disappears fraction): within 6 months; usually indicates recent infection HBeAg (e antigen): * a marker for particular infectiousness Specific Prevention: * hepatitis B immune globulin (passive immunization) * hepatitis B vaccine (active immunization) Specific Treatment: * interferon alpha (for some cases of chronic hepatitis B) Source: Benenson, A.
Antibody production to hepatitis B core antigen
(anti-HBc) is detectable following a 4-12 week incubation period.
HIV p24 core antigen
, a protein component of the AIDS virus.