complement fixation test

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  • noun

Words related to complement fixation test

a blood test in which a sample of serum is exposed to a particular antigen and complement in order to determine whether or not antibodies to that particular antigen are present

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These include 1) a complement-fixation test that is relatively insensitive because in 25% of patients complement-fixing antibodies are not detected and in 75% of patients these antibodies appear late after infection; 2) a seroneutralization assay for detection neutralizing antibodies that appear 14-21 days after onset of disease; 3) an immunofluorescence assay that uses CTFV-infected BHK-21 or Vero cells and is an easy and rapid test for detecting anti-CTFV antibodies; and 4) an enzyme-linked immunosorbent assay (ELISA) for immunoglobulin M (IgM) and IgG that appear concurrently or a few days after neutralizing antibodies (peak 30-40 days after infection), However, IgM titers decrease sharply after day 45.
Immunodiffusion and complement-fixation serologic tests were performed at the Centers for Disease Control and Prevention (CDC).
burnetii in acute- and convalescent-phase serum samples by complement-fixation test (CFT) or indirect immunofluorescence assay (IF).
Seven virus isolates were obtained and identified by complement-fixation and neutralization tests.
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