Structure and function of the complement receptors
, CR1 (CD35) and CR2 (CD21).
Duplication and divergence of the amino-terminal coding region of the complement receptor
1 (CR1) gene.
Thornton BP, Vetvicka V, Pitman M, Goldman RC, Ross GD (1996) Analysis of the sugar specificity and molecular location of the [beta]-glucan-binding lectin site of complement receptor
type 3 (CD11b/CD18).
Celldex) reported that the first patient has been dosed in its pilot study of CDX-1135 (a soluble form of human complement receptor
type 1) in dense deposit disease (DDD).
A team of researchers now reports the identity of this protein as the complement receptor
1 (CR1), also known to help protect red cells from attack by the immune system.
TP10 is a soluble form of complement receptor
1, a naturally occurring protein found on blood cells.
7,759,304, entitled "Targeting Complement Factor H For Treatment of Diseases", covering the composition of matter for its lead product candidate, TT30, a novel fusion protein that selectively binds to complement activated cells to locally regulate the complement system, as well as other complement receptor
2-Factor H (CR2-FH) fusion compounds.
Oral presentation, Targeted Therapies/Inhibitors, Abstract #14, "The human complement receptor
type 2/factor H fusion protein TT30, an alternative pathway specific complement inhibitor, prevents hemolysis of erythrocytes from patients with paroxysmal nocturnal hemoglobinuria by membrane-targeting of factor H activity", Risitano, et.
TT30 is a fusion protein coupling domains from complement receptor
2 (CR2) with the alternative pathway inhibitor factor H (fH).
Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor