Because the SBA protocol uses a standardized exogenous complement source, a complement deficiency
in tested serum samples would not influence the assay results.
Varicella and MMR vaccines can be administered to children with chronic granulomatous disease, congenital and cyclic neutropenia and complement deficiency
One test available for complement deficiency
, although only in some centres, involves total haemolytic complement screening.
Updated recommendations in effect in 2010 state that those at highest risk for meningococcal infection (those with functional or anatomic asplenia, C3 complement deficiency
, or HIV infection) should be vaccinated with MCV4 starting at age 2 and revaccinated every 3 years if last vaccinated at 2 to 6 years, and every 5 years if last vaccinated at or after age 7.
Other high-risk groups that should be vaccinated include military recruits, travelers to areas where meningococcal disease is hyperendemic or epidemic, microbiologists who are routinely exposed to isolates of Neisseria meningitidis, and people with anatomic or functional asplenia or terminal complement deficiency
In addition, there will be a footnote stating that these recommendations for a three-dose schedule do not apply to children under the age of 15 years with asplenia, asthma, chronic granulomatous disease, chronic heart/liver/lung/renal disease, central nervous system anatomic barrier defects, complement deficiency
, diabetes, or sickle cell disease.