Nerve cells are uniquely vulnerable to activation of the complement cascade
Innate immunity of the sinonasal cavity: Expression of messenger RNA for complement cascade
components and toll-like receptors.
This is the reason we studied possible interference with the complement cascade
by plants from the pharmacopoeia of Tacana Indians.
8% in patients who received a bolus plus 20-hour infusion of pexelizumab in order to selectively inhibit part of the complement cascade
for 24 hours.
The sCR1 protein component of the molecule is a potent inhibitor of both the classical and alternative complement cascades
, which are implicated in a wide range of diseases including ischemia-reperfusion (heart attack, stroke), transplantation and chronic inflammatory diseases (arthritis, multiple sclerosis).
Furthermore, through what's called the alternate pathway, the complement cascade
can sometimes proceed even without alpha-gal antibodies.
Alexion's C5 complement inhibitors are specific and potent recombinant anti-inflammatory drugs which are designed to intervene in the complement cascade
Decorin also binds and inhibits an enzyme, C1q, that is a critical component of the complement cascade
that moderates a variety of inflammatory responses in the body.
That's because chicken Fc fragments can't trigger the so-called complement cascade
in humans -- the intense inflammatory reaction that underlies many of the more serious symptoms of serum sickness and anaphylaxis.
In targeting the Complement cascade
in the innate immune system, iPierian's platform is being leveraged to tease out specific mechanisms of chronic inflammation that occur in various brain disorders.
The researchers suggest that stopping the complement cascade
could eliminate the major cause.
By blocking the two key pathways of complement activation (the C3 and C5 convertases) early within the complement cascade
, MLN2222 may reduce tissue injury in multiple organ systems, reducing the mortality and morbidity associated with CABG surgery employing CPB.
The study further shows that microglia take their cues from neurons' activity patterns and from a set of signals called the complement cascade
, used by the immune system to rid the body of unwanted pathogens and debris.
In contrast to APT070, which acts early in the complement cascade
, CD59-Prodaptin(TM) interrupts the formation of the "membrane attack complex" which is responsible for killing cells.
Activation of the complement cascade
has been implicated in the pathogenesis of many inflammatory diseases, including rheumatoid arthritis, asthma, ischemia-reperfusion injury and age-related macular degeneration.