While the previous generation of p38 MAPK inhibitors suffered from side effects such as liver transaminase elevations, the newer inhibitors are more selective at targeting p38 and include non-ATP competitive inhibitors
directed against the conformation epitope.
One key differentiator of BNC420 is that it displays significant selectivity to VEGFR3 over related VEGFR receptors, while other competitive inhibitors
of the VEGFR receptors (e.
The new dimerization inhibitor unveils a biologically meaningful rationale for suppressing angiogenesis in tumors that could outperform traditional competitive inhibitors
of angiogenesis in tumor therapy.
5 [mu]M); medium competitive inhibitors
of CYP2C9 ([K.
Vast libraries of ATP competitive inhibitors
offer the promise of easy success in the search for new kinase inhibitors.