The role of the C-terminal domain in collagenase
and stromelysin specificity.
13) There is a strong correlation between the production of inactive collagenase
and responding fibroblasts.
SalA showed selectivity on gelatinase (MMP-2 and MMP-9) than on collagenase
(MMP-8 and MMP-13) in vitro, and specificity on MMP-9 than MMP-2 in vivo.
Lowdose doxycycline therapy: effect on gingival and crevicular fluid collagenase
activity in humans.
is a drug that breaks down collagen in damaged tissue and helps healthy tissue to grow.
The FDA's Arthritis Advisory Committee voted 12-0 that the treatment, collagenase
Clostridium histolyticum, should be approved for treating advanced Dupuytren's, based on the available safety and efficacy data.
Most patients developed autoantibodies to the two collagenases
, but this did not appear to affect responses to treatment.
Comparative immunolocalization studies of collagenase
1 and collagenase
3 production in the rheumatoid lesion, and by human chondrocytes and synoviocytes in vitro.
21] This essentially means that debridement could be achieved with a less expensive hydrogel since it is the moisture in the wound that is responsible for facilitating debridement--especially since collagenases
often cost between $70 and 100 per tube.
Behind collagen's breakdown were enzymes, such as collagenases
To remove the ECM, vegetal isolates were treated with collagenases
F, H, L, or N, singly, or in combination with pancreatin or with pancreatin alone.
clostridium histolyticum is a combination of two purified collagenases
is an enzyme capable of breaking down collagen), derived from the bacterium Clostridium histolyticum.
Herbal extracts are also potent inhibitors of pathologically elevated collagenases
and hence may be used as an alternative adjunct in the management of periodontal disease.
Activity of type IV collagenases
in benign and malignant breast disease.
Strauss III, director of the Center for Research on Women's Health and Reproduction at the University of Pennsylvania in Philadelphia, and his colleagues focused on a family of enzymes called collagenases