collagen

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  • noun

Words related to collagen

a fibrous scleroprotein in bone and cartilage and tendon and other connective tissue

References in periodicals archive ?
The discovery arose from a study of children with a blistering skin disorder caused by a defective or missing collagen VII protein
The work, which appears in the March 18 issue of Science, is the first published research implicating the protein, collagen VII, in cancer.
The finding came about because roughly two-thirds of children with a blistering skin disorder called recessive dystrophic epidermolysis bullosa, or RDEB -- caused by a mutation that leads to an altered or missing collagen VII protein -- develop a type of skin cancer called squamous cell carcinoma.
What Khavari and postdoctoral scholar Susana Ortiz-Urda, MD, PhD, found is that a fragment of collagen VII is required for the skin cancer cells to break free from the neighboring skin tissue and spread -- a step that turns an otherwise benign tumor into a killer.
It turns out that the difference in cancer formation had to do with the type of alteration in the children's collagen VII gene.
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