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The results suggest that Egyptian cobra venom stimulates oxidative stress to induce apoptosis in renal tissue through inhibition of mitochondrial respiration in male rats.
Keywords: Egyptian cobra venom renal toxicity oxidative stress apoptosis.
6) Cobra venom contains cobratoxin and a-bungarotoxin which act postsynaptically by binding to acetylcholine receptors on the motor end plate while (3-bungarotoxin and crotoxin present in krait venom act pre-synaptically and prevent release of acetylcholine at the neuromuscular junction resulting in muscle paralysis due to curare like neuromuscular blocking action affecting the muscles of eyes, throat and chest leading to respiratory failure.
Phospholipase A2 in cobra venom was shown to have additional neuromuscular blocking activity in vitro.
The production of cobra venom for use in antisera manufacturing is well established and could be scaled-up to meet the demands for anti-retroviral therapy.