The limitations of this study were the low number of patients and the lack of routine screening of rare coagulation defects
(II, V, VII, X, XI, XII, XIII) when PT, PTT, and TT were normal.
1) Lastly, a child that has bruises in the "typical" distribution but seems to "over bruise" in these areas may have an underlying mild coagulation defect
Many of the patients were affected by two or more different coagulopathies, and one patient was diagnosed with five different coagulation defects
Screening tests for coagulation defects
can be run in most clinical laboratories.
The report, Neonatal Encephalopathy and Cerebral Palsy: Defining the Pathogenesis and Pathophysiology, gives evidence that the vast majority of neonatal encephalopathy and cerebral palsy originate from developmental or metabolic abnormalities, autoimmune and coagulation defects
, infection, trauma or combinations of these factors.
The report "Neonatal Encephalopathy and Cerebral Palsy: Defining the Pathogenesis and Pathophysiology" gives evidence that most neonatal encephalopathy (NE) and cerebral palsy (CP) cases originate from developmental or metabolic abnormalities, autoimmune and coagulation defects
, infection, trauma, or combinations of these factors.
The other 5 patients carried other inherited coagulation defects
, in addition to SPS.
Vomiting, trauma, coagulation defects
, and cough have been reported as causes.