A simplified schematic representation of the coagulation cascade
and fibrinolytic system.
There are seven vitamin K-dependent blood clotting ('coagulation') factors, and they are each important in the coagulation cascade
that helps form a clot.
16 Also, there exist some abnormalities especially in the fluid phase of the coagulation cascade
which may produce bleeding in the HIV patient.
First-line therapy for hemostasis is recombinant activated factor VII or activated prothrombin complex, which bypasses the factor VIII inhibitor in the coagulation cascade
46) Because avian species do not have a well-developed intrinsic pathway, (6,13-15) this activation method may have resulted in incomplete initiation of the coagulation cascade
TF may play an important role in this hypercoaguable state through activation of the coagulation cascade
It clearly shows that thrombin plays a pivotal role in the coagulation cascade
and protamine reverses the effect of heparin which blocks the activity of thrombin.
DTIs target the final step in the coagulation cascade
, thereby inhibiting the conversion of fibrinogen to fibrin and subsequent thrombus formation.
The D-dimer antigen is a product of fibrin degradation that is formed by the sequential action of enzymes of coagulation cascade
Platelet dysfunction and abnormalities in coagulation cascade
can accelerate atherogenesis in diabetic patients.
It provides information on clot initiation, clot growth, final clot strength, and presence of fibrinolytic clot breakdown, giving a global evaluation of all phases of the coagulation cascade
(Schochl et al.
Available literature on the topic identifies the contact between blood and the dialyzer as the primary trigger for the coagulation cascade
during hemodialysis (Frank et al.
ii) Dabigatran versus warfarin: The clinical effectiveness of dabigatran, which acts the end of the coagulation cascade
, seems to be very different from the effect of warfarin, which acts almost at all levels of the cascade, despite having similar effects in terms of incidence of bleeding, treatment with Dabigatran did not require continuous monitoring and was not associated with the emergence of significant adverse effects.
Acute inflammatory events, such as those that occur in ALI, lead to dysregulation of the coagulation cascade
3 Bleeding manifestations may occur as a single clinical phenomenon or may be part of a complex derangement of the coagulation cascade
due to DIC in gram negative sepsis.