Second, it seems at least theoretically possible to include circulating factors other than gut hormones in an analogous single-molecule co-agonist
," he added.
Lilly already has several multi-specific therapeutics in preclinical development, including a co-agonist
peptide being studied as a potential treatment for diabetes that is anticipated to enter clinical development by the end of this year.
5, 2010 /PRNewswire/ -- EnVivo Pharmaceuticals today announced it has discovered that EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist
with Acetylcholine (ACh) to enhance cognition.
Licostinel, an NMDA receptor antagonist acting at the glycine co-agonist
site, was studied in a series of Phase I clinical trials from 1995 until earlier this year.
This research increases our understanding of how EVP-6124 enhances synaptic transmission in the brain and acts as a co-agonist
in combination with the body's own natural acetylcholine response to enhance cognition," said Gerhard Koenig, Ph.