There is an increased risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume or concurrent administration of certain CNS depressant
drugs (eg, phenothiazines or general anesthetics).
It can interact with numerous medications, including other medications affecting serotonin (eg, selective serotonin reuptake inhibitors), other CNS depressants
(eg, alcohol), ketoconazole, and itraconazole.
For example, when cough syrup containing the CNS depressant
dextromethorphan (DXM) is abused or mixed with other drugs, the syrup can contribute to car accidents when the abuser is slow or unable to react.
The concomitant use of CNS depressants
can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.
Combination with other CNS depressants
has an additive effect, increasing the risk of coma and death.
It can interact with CNS depressants
and stimulants, and tolerance often develops.
Benzodiazepines may also cause physical side effects such as vertigo and they often have additive effects when used in conjunction with other CNS depressants
One noticeable omission is the absence of any mention of the relatively new "date rape" drugs, flunitrazepam and y-hydroxybutyrate, in the chapter on CNS depressants
Interactions with CNS Depressants
and Illicit Drugs Hypotension, profound sedation, coma, or respiratory depression may result if oxymorphone hydrochloride extended-release tablets are used concomitantly with other CNS depressants
Do not drink alcohol, or take other CNS depressants
such as cough and cold medicines, certain pain medicines, and medicines that help you sleep while you take Diclegis.