Subgroup analyses of patients with clear cell carcinoma
(n = 544) showed results similar to those observed in the main cohort analysis.
25) Other lesions that need to be distinguished from clear cell adenocarcinoma include vaginal or cervical clear cell carcinomas
, clear cell prostatic adenocarcinoma, and metastatic clear cell renal cell carcinoma.
The letter by Drs Woods, Garib, and Andea illustrates a very nice example of adnexal clear cell carcinoma
with comedonecrosis (ACCCC), a putative new clinicopathologic entity we recently described in the ARCHIVES.
The wide expression of CD10 in healthy tissue is matched by its expression in a growing list of neoplasms, often with a high percentage (20%-100%) stained, including in cutaneous adnexal neoplasms, (18) malignant mesotheliomas, (19) epithelioid hemangioendotheliomas, (64) ovarian clear cell carcinomas
, (33) urothelial carcinomas, (22) prostatic adenocarcinomas, pancreatic adenocarcinomas, hepatocellular carcinomas, colonic adenocarcinomas, malignant melanomas, spindle cell sarcomas, lung carcinomas, ovarian carcinomas, endometrial stromal sarcomas, and pancreatic solid pseudopapillary tumors.
Activation of the mTOR signaling pathway in renal clear cell carcinoma
Histology revealed clear cell carcinoma
Fuhrman grade VI (pT3c).
Microscopically, the polypoid mass showed a clear cell carcinoma
focally lined by gall bladder mucosa similar to that seen in the previous nephrectomy (Figure 2, C and D).
ENMD-2076 is currently in Phase 2 advanced soft tissue sarcoma and Phase 2 ovarian clear cell carcinoma
, trials at Princess Margaret Cancer Centre in Toronto.
Clear cell carcinoma
shows marked cytologic atypia and numerous mitotic figures, at least focally.
Metastatic clear cell carcinoma
encompasses a collection of lesions composed of cells that exhibit a clear or glycogenated cytoplasm and commonly arises in 2 sites, the kidney and the gynecologic tract, including the ovary and endometrium.
Lesions that are characteristic of a specific renal tumor type (loss of 3p for clear cell carcinoma
, trisomy 7 and/or 17 for papillary RCC, and normal karyotype for oncocytoma) were identified in all 19 cases by v-karyotype and in 15 cases by CG.
To Expand Clinical Trial for Advanced Ovarian Clear Cell Carcinoma
The tumor was almost exclusively composed of epithelioid cells, which had abundant clear cytoplasm and small- to medium-sized, round to oval nuclei and a thin, fibrous septum with abundant capillary networks, reminiscent of clear cell carcinoma
of the kidney.
Our clinical trials in triple-negative breast cancer, soft tissue sarcoma and ovarian clear cell carcinoma
are underway in the US and Canada with plans to expand the trials into China.
Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma