While there are three features that form the classic triad
of MRS, they are rarely encountered at the time of presentation, making the diagnosis challenging.
The classic triad
of symptoms in patients with pyometra consists of purulent vaginal discharge, postmenopausal bleeding and lower abdominal pain.
The diagnosis of MRS is difficult because the syndrome does not occur with all three signs of the classic triad
Wernicke encephalopathy presents clinically as the classic triad
of encephalopathy, oculomotor dysfunction, and gait ataxia; however, the combination of all three is only observed in one-third of patients with WE.
In a series of 101 patients with CNS infection, the classic triad
seen with bacterial brain abscess--fever, headache, and neurologic deficits--was present in fewer than 5% of patients (Clin.
A classic triad
of spongiform change, neuronal loss, and astrocytosis has been well described (figure 4).