Clara cell secretory protein oxidation and expression in premature infants who develop bronchopulmonary dysplasia.
CCSP protein in distal airways of late control (E) and late BPA exposed (F) was expressed in cells resembling Clara cells (arrows).
104) The expression of Clara-cell differentiation antigens in NSCLC is unexpectedly low, (105) but the relevance of Clara cells
as epithelial cell precursors in humans is not as clear as it appears in the mouse.
We exposed murine Clara cells
, which are known to express functional Nat2, the murine ortholog of human NAT1 (Kawamura et al.
These findings suggest that Clara cell injury by bioactivated chemicals in the developing animal is not necessarily predicted by the level of CYP450 enzyme activity.
Neonatal Clara cell toxicity by 4-ipomeanol alters bronchiolar organization in adult rabbits.
Inhaled naphthalene causes dose dependent Clara cell toxicity in mice but not in rats.
Pulmonary heat shock protein expression after exposure to a metabolically activated Clara cell toxicant: relationship to protein adduct formation.
The researchers theorize that repeated exposure to disinfection by-products around indoor swimming pools may damage Clara cells
, decreasing production of CC16 and possibly masking any effect that ozone exerts on CC16 levels.
Our results indicate that repeated exposure to chlorination by-products in the air of indoor swimming pools has an adverse effect on the Clara cell function in children, such that the anti-inflammatory role of CC16 in the lung could be diminished.
Transient increase of Clara cell protein (CC16) after exposure to smoke.
In the two crystalline silica-exposed groups, the MMP-9 expression increased after 7 days of exposure and was statistically significantly higher in the Clara cell-ablated group than in the group of mice with Clara cells after 14 days of exposure.
However, no newly strongly stained cell types were found after both crystalline silica exposure or Clara cell ablation.
Determinants of Clara cell
protein (CC16) concentrations in serum: a reassessment with two different immunoassays.
Gestational SS-induced effect on Clara cells
is blocked by MM.