The following key words and subject terms were searched: Clara cell
10-kDa protein CC10 CC16 SCGB1A1 uteroglobin asthma genetic and polymorphism.
Tumor necrosis factor alpha stimulation of human Clara cell
secretory protein production by human airway epithelial cells.
In experimental animals, injury models have shown that rapid bronchiolar repair can be mediated by different cell types, including naphthalene-resistant Clara cells
(nonciliated, columnar secretory cells that can act as facultative airway progenitors), bronchioloalveolar stem cells that can maintain both Clara cells
and alveolar pneumocytes, and also differentiated ciliated cells.
Impairment of the endogenous NAT-dependent biotransformation pathway in lung epithelial Clara cells
Similarly, naphthalene, another bio-activated Clara cell
toxicant, has been found to induce injury at much lower doses in immature mice (Fanucchi et al.
Early events in naphthalene-induced acute Clara cell
3] exposure leads to an increased number of Clara cells
in the central acinus, which can produce both PG[E.
They conclude that Clara cell
damage associated with indoor pool use may diminish the antiinflammatory effect of CC16 in the lung.
One of these, Clara cell
protein (CC16), is a small, 16-kDa protein produced and secreted by the nonciliated bronchiolar Clara cells
and detectable in serum.
For example, they secrete Clara cell
secretory protein (CCSP) (9), which inhibits pulmonary inflammation (10); surfactant proteins, which prevent alveolar collapse (11-15); and protease inhibitors such as secretory leukocyte protease inhibitor (SLPI) (16-18) and elafin (17,18).
8-kDa Clara cell
protein (CC16 or CC10), which is secreted in large amounts at the surface of airways from where it leaks into the serum, most likely by passive diffusion (5-8).
One type, known as variant Clara cells
, however, resisted damage from those substances.
Dr Whitsett and his team at Cincinnatti Children's team Hospital found "good" lung cells called Clara cells
change into mucus cells in a process called metaplasia - and that the process could be reversed.
Mucinous type is composed of mucous (goblet) cells, while nonmucinous type has clara cells
and type II cells.
2009), whereas Clara cells
and goblet cells express CCSP and SPDEF, respectively.