0 Bupropion hydroxylation CYP2B6 50 Amodiaquine N-deethylation CYP2C8 5 Diclofenac 4'-hydroxylation CYP2C9 10 Omeprazole 5-hydroxyladon CYP2C19 20 Dextromethorphan O-deethylation CYP2D6 5 Chlorzoxazone
6-hydroxylation CYP2E1 50 Midazolam 1-hydroxylation CYP3A4 2.
CYP2E1 activity was assessed by the formation of 6-hydroxychlorzoxazone from the CYP2E1 probe chlorzoxazone
(Wang et al.
Key words: chlorzoxazone
, CYP2E1 mRNA induction, lymphocytes, occupational exposure, toluene.
Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazone
hydroxylation in alcoholics during the withdrawal phase.
Until now, the "gold standard" method for CYP2E1 phenotyping has used a probe drug, chlorzoxazone
(CZX), administered orally (500 or 250 mg) to fasting individuals and metabolized to 6-hydroxychlorzoxazone (HCZX) by CYP2E1.
Tenders are invited for Tab Chlorzoxazone
500 Mg And Paracetamol 325 Mg With Diclofenac Sod.
Phenacetin, paracetamol, warfarin, tolbutamide, 4-hydroxy-methyltolbutamide, dextromethorphan, dextrorphan, chlorzoxazone
, 6-hydroxyl-chiorzoxazone, testosterone, 6[beta]-hydroxyl testosterone, chlorpropamide, chlorpheniramine, [beta]-nicotinamide adenine dinucleotide phosphate (NADP), glucose-6-phosphate, glucose-6-phosphate dehydrogenase and other unspecified reagents were purchased from Sigma Chemical Co.
For example, dextromerhorphan and debrisoquine are known substrates for a particular cytochrome P450 (CYP) enzyme, CYP2D6; trimethadione, chlorzoxazone
, and halothane are markers for CYP2E1 activity; morphine is predominantly processed by glucuronidation; and a host of antibiotics are not extensively metabolized but are mostly excreted unchanged by the kidneys (Bertz and Granneman 1997; Dollery 2000; Kurata et al.
Recent studies involving this probe to correlate chlorzoxazone
6-hydroxylase activity (phenotype) with the known polymorphisms of CYP2E1 failed to demonstrate a relation between altered CYP2E1 genotype and the capacity to metabolize chlorzoxazone
Tenders are invited for Supply of Tablet / Capsule Containing Chlorzoxazone
500Mg Plus Diclofenac Sodium 50Mg Plus Paracetamol 325Mg In Strip
Metabolism of dextromethorphan to dextrorphan (CYP2D6-mediated) and chlorzoxazone
to 6-hydroxychlorzoxazone (CYP2E1-mediated) was only minimally inhibited by PSP, with [IC.
Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C [right arrow] T mutation and rapid fractional excretion of chlorzoxazone
Phenacetin, paracetamol, warfarin, furafylline, testosterone, 613-hydroxytestosterone, ketoconazole, 4-hydroxytolbutamide, tolbutamide, chlorzoxazone
, 6-hydroxychlorzoxazone, chlorpropamide, chlorpheniramine, dextromethorphan, dextrorphan, sodium diethyl-dithiocarbamate, glucose 6-phosphate dehydrogenase (G6PDH), D-glucose 6-phosphate (G6P), [beta]-nicotinamicle adenine dinucleotide phosphate (NADP), and Tris-HCI were purchased from Sigma Chemical Co.
Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone
metabolism in rat liver.
1), on human CYP1A2, 2C9, 2E1 and 3A4 catalytic activity was investigated in vitro to determine the potential of Danshen in affecting CYP mediated phase I metabolism in human, using phenacetin (CYP1A2), tolbutamide (CYP2C9), chlorzoxazone
(CYP2E1) and testosterone (CYP3A4) as the respective probe substrates.