21] The muscularis mucosa is still visible and quite intact, but its surface is starting to erode, the adipose tissues are starting to invade, the chief cells
are degrading, and the parietal cells are redilating due to necrosis.
Photomicrograph showing chief cells
, which are focally and weakly immunoreactive for chromogranin (original magnification X20).
1996) (28) reported that the oxyphil cells are the result of proliferation of mitochondria in the chief cells
C, Multiphoton microscopy reveals individual gastric oxyntic glands that are separated by a mesh of collagen fibers at the deeper part of the mucosal layer ([greater than or equal to] 60 m depth) D, The corresponding light-microscopic image shows there are chief cells
and parietal cells in each gastric gland (hematoxylin-eosin, original magnifications x400 [B and D]).
Citation: "Differentiated Troy+ chief cells
act as 'reserve' stem cells to generate all lineages of the stomach epithelium"; Stange DE et al.
The strong cytoplasmic staining of PTH in chief cells
is readily identifiable.
Histopathologic examination revealed that parts of the tumor contained a lobulated architecture composed of sheets, cords, and follicles of chief cells
, oxyphil cells, and clear cells; these findings were consistent with an adenoma.
Immunohistochemistry confirmed the presence of 2 cell populations: the chief cells
stained with neuron-specific enolase and chromogranin, whereas the sustentacular cells stained with S100 protein.
Chromogranins are proteins within the chief cells
, and S-100 is produced by sustentacular cells (SY38 is another, less specific, marker for neuroendocrine tumors).
Histologically, the cells resemble chief cells
and are uniform, with clear to amphophilic cytoplasm surrounding small, hyperchromatic nuclei (figure, B).
Microscopic examination of the biopsy specimen of the left inferior parathyroid gland showed only chief cells
The thymic tissue appeared as a single lobule divided by fine, fibrous septa, and the parathyroid tissue was made up entirely of chief cells