Eosinopenia of acute infection: production of eosinopenia by chemotactic factors
of acute inflammation.
recruit more of these cells to the site, and the destructive process perpetuates.
It is unknown whether these cells migrate randomly or as a response to certain chemotactic factors
, but it is reported that many factors are of importance in the transformation of the mesenchymal cells into osteoblasts (1).
The mast cell's ability to synthesize and release cytokines such as interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 13 (IL-13) and other chemotactic factors
has given acceptability to its role in the asthmatic inflammatory response, and the chemical pathway to inducing fibrosis is of particular interest.
The damaged endothelial cells release chemotactic factors
which lead to the accumulation of low density lipoproteins (LDLs) from the plasma which become oxidised.
PVL toxin creates lytic pores in the cell membrane of neutrophils and induces the release of neutrophil chemotactic factors
that promote inflammation and tissue destruction (Kollef & Micek, 2006).
Lyn was found to be important for NFr, B mediated increased expression and release of macrophage chemotactic factors
(MCP-1 secretion) that recruit alveolar macrophage (AM) to the site of infection.
Some of these were present in more than 3 samples: growth factors (fibroblast growth factor 4, placental growth factor), chemotactic factors
[B lymphocyte chemoattractant/CXCL13, macrophage inflammatory protein (MIP)-1[beta]/CCL4, MIP-1[delta]/ CCL15, MIP-3[alpha]/CCL20, pulmonary and activation-related chemokine (PARC)/CCL18, leukemia inhibitory factor, oncostatin M], and antiinflammatory factors [tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, macrophage-derived chemokine (MDC)/CCL22].
Homocysteine increases the production of proinflammatory cytokines and expression of adhesion molecules and chemotactic factors