Charcot-Leyden crystals (CLCs) are accepted as a morphologic hallmark of eosinophil-related disease in which there is active eosinophilic inflammation or proliferation.
Formation of Charcot-Leyden crystals in human eosinophils and basophils and study of the composition of isolated crystals.
These cases demonstrated the ultrastructural features of Charcot-Leyden crystals.
In the present study, we describe 2 cases of GS with numerous needlelike crystals, which had the ultrastructural features of Charcot-Leyden crystals.
Charcot-Leyden crystals consist of a 13 000-molecular weight acidic protein whose amino acid composition distinguished it from the 9300-molecular weight major basic protein, the principal constituent of eosinophil large granules; this protein is identical to lysophospholipase (3) and is stained by basic fuchsin in the Ziehl-Neelsen method.
Circulating Charcot-Leyden crystals in the hypereosinophilic syndrome.
The minor criteria include asthma, unilateral predominance, radiographic bone erosion, fungal culture, Charcot-Leyden crystals
, and serum eosinophilia.
New observations include Charcot-Leyden crystals
(Figure 4) and association with celiac disease, lupus anticoagulant, and new viral and bacterial infectious agents.