Keeping the importance of cupric Cu in biological function, an elaborate mechanism is set forth by Nature for maintaining Cu homeostasis, which includes a wide array of proteins namely (i) family of Cu bearing proteins, (ii) cuproenzymes, (iii) Cu transporters and (iv) Cu chaperone proteins
The final straw could be the loss of chaperone proteins
, which oversee protein-folding, or a strike by the cellular machinery that transports or breaks down proteins, causing crowding in the cell that foments aggregation.
typically help ensure that tau proteins are properly folded to maintain the healthy structure of nerve cells.
The article reports on certain aspects of MANFtrafficking inside the cell and its secretion outside the cell, as well as MANF's interactions with other chaperone proteins
of the endoplasmic reticulum (ER).
The unfolded protein response maintains a balance between unfolded proteins and chaperones by regulating the rate of transcription and translation of chaperone proteins
(David Ron, University of Cambridge, Cambridge, UK).
By better defining the mechanisms linking chaperone proteins
to both the tau aggregation and degradation pathways, we can move toward more individualized, effective therapies targeting Alzheimer's and other distinct neurological disorders," said Dickey.
Finally, the work shows for the first time how members of the hsp90 family of chaperone proteins
can differ from each other, while still being part of the same overall family.
Hunt's postdoctoral research focused on X-ray crystallographic studies of molecular chaperone proteins