Cell apoptosis is a severe consequence to cerebral ischemia
and prevention of apoptosis is a critical step for clinical treatment (Ferrer and Planas 2003).
Administration of N-acetylcysteine after focal cerebral ischemia
protects brain and reduces inflammation in a rat model of experimental stroke.
We investigated the effects of GTPs on the expression of claudin-5, occludin, and ZO-1, and the corresponding cellular mechanisms involved in the early stage of cerebral ischemia
It should be kept in mind that this clinical picture in the pathogenesis of which hyperglycemia, cerebral ischemia
and consumption of GABA are thought to be involved and which generally improves with regulation of blood glucose may be the first cause of presentation to the emergency department especially in patients whose diabetes is not known and rapid intervention should be performed.
For example, it inhibits apoptosis associated with cerebral ischemia
They discuss the underlying basic science and cerebrovascular physiology of the critically ill neurological patient, hypertensive emergency, airway management, traumatic brain injury and intracranial hypertension, acute spinal cord injury, subarachnoid and intracerebral hemorrhage, cerebral ischemia
, and epilepsy, and critical aspects related to cerebrovascular disease, infections of the nervous system, neuromuscular disorders, and neurological complications and consultations in general intensive care, ending with a section on neuroimaging and neuromonitoring.
In the January issue of Clinical Chemistry, Foerch and colleagues (1) report on the diagnostic accuracy of plasma glial fibrillary acidic protein (GFAP)  for differentiating intracerebral hemorrhage (ICH) and cerebral ischemia
in patients with symptoms of acute stroke.
In embryonic neuronal cultures, nPM impaired neurite outgrowth, and this effect was blocked by AP5- These results suggest that exposure to nPM could exacerbate conditions involving glutamatergic excitotoxicity, such as cerebral ischemia
Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia
in wild-type and tPA-deficient mice.
2010 Preventive effect of silymarin in cerebral ischemia
reperfusion-induced brain injury in rats possibly through impairing NF-[kappa]B and STAT-1 activation.
Their topics include how clinical reality should instruct stroke modeling, focal cerebral ischemia
in the mouse and rat using the intraluminal suture-filament model, photochemical and endothelin models of focal brain ischemia, noninvasive brain imaging in small animal stroke models with MRI and PET, behavioral testing in mouse models of stroke, ethics of modeling cerebral ischemia
in small animals, and statistics in experimental stroke research from sample size calculation to data description and significance testing.
The goal in the presentation of these case reports is to discuss preoperative angiographic findings and different monitoring options for cerebral ischemia
prevention during removal of carotid body tumors (3,4).
Cerebrovascular disease is another possibility, even though another analysis adjusting for acute stroke and transient cerebral ischemia
in this study population did not fully account for the effect of hypoglycemia.
Animal work suggests that the brain releases large amounts of ascorbic acid in response to cerebral ischemia
, perhaps to act as a scavenger of free radicals (15) or to prevent glutamate toxicity.
Of those that survive beyond resuscitation, up to 30% will develop widespread cerebral ischemia
and edema that frequently lead to severe neurological impairment.