Both chromosomes have heterochromatin on the centromere
of this homeologous chromosome pair, while duplication of a portion of the centromeric heterochromatin may have modified the chromosome morphology.
Another similarity between plant and animal chromatin is the presence of specific histone H3 variants, called centromeric H3 (CenH3s), which are known to replace histone H3 in centromere
chromatin (Cooper & Henikoff, 2004).
The way in which a vital protein is loaded by others into the centromere
, the part of the chromosome that plays a significant role in cell division, has been identified by biologists.
One of the specific autoantibodies, such as anti-double-stranded DNA (anti-dsDNA), usually shows relatively low titers in ANA, whereas others, such as anti-U1RNP and centromere
, may lead to very high titers of positive ANA, irrespective of the clinical and life-threatening severity.
Chromosomes with two centromeres
are mitotically unstable.
is functional, but it isn't wrapped in a blanket of repetitive DNA, suggesting the repetitive elements aren't necessary for a centromere
are key structural features of chromosomes that are necessary for the movement of chromosomes when cells divide, a function that ensures normal distribution of all genetic material to each daughter cell.
FISH probes (non-commercial) for centromeres
of chromosome X, Y, 1 and 18 were used for the study.
Distinct DNA-binding proteins are also associated with origins of DNA replication, centromeres
, telomeres, and other aspects of genome maintenance (5, 6).
Three-dimensional arrangements of centromeres
and telomeres in nuclei of human and murine lymphocytes.
other diseases nucleosome) Peripheral/rim DNA, nuclear envelope SLE, autoimmune hepatitis antigens Speckled Smith, RNP, SS-A, SS-B, SLE, MCTD, Sjogren, Scl-70, centromere
, RNA PSS, other diseases polymerase II and III Nucleolar Nucleolar RNA, RNA Diffuse systemic sclerosis, polymerase I hepatocellular carcinoma Centromeric Centromeres
Limited cutaneous systemic sclerosis (a) SLE, systemic lupus erythematosus; MCTD, mixed connective tissue disease; PSS, progressive systemic sclerosis.
We have mapped the chromosomal location of eight genes relative to their centromeres
and have identified a linkage relationship between glucose phosphate isomerase-B and the sex-determining gene in channel catfish.
In the present study, we have employed a combination of time-lapse photography of living cells and FISH in an effort to elucidate the mechanisms of rosettes assembly and the role of centromeres
in this process in human diploid fibroblasts (HDFs).
In addition, the identification of nucleic acid sequences that function as plant centromeres
has allowed Chromatin to generate stably inherited DNA constructs and mini-chromosomes in several plant species.
specification relies on epigenetic mechanisms, the most prominent of which is identified in the enrichment at centromeres
of the histone H3 variant CENP-A.