Leydig cell

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Related to Cells of Leydig: Leydig cell tumor
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Synonyms for Leydig cell

a cell in the testes that secretes the hormone testosterone

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The results of the present work showed that lead exposure caused testes atrophy manifested by distorted and shrunkn seminiferous tubules with thick and irregular membrane, degenerated spermatogonia and spermatocytes, absence of spermatids and mature sperm and reduction in the interstitial cells of leydig, this could be due to distribution of lead in the seminiferous tubules via blood stream and then absorbed lead caused mechanism of toxicity in the seminiferous tubules.
Neuronal losses in the hypothalamus will dysrupt the hypothalamus-pituitary-testis regulatory axis which result in loss of or considerable reduction in the testosteron synthesis ability of testicular interstitial cells of Leydig.
Impairment in the production of the releasing factor by the hypothalamus, may adversely affect the testosterone--synthesizing ability of the the interstisial cells of Leydig whose function has been shown to be dependent on the stimulation by pituitary interstitial cell stimulating hormone [20].