Later chapters detail strategies for the development and targeting of peptide drugs, with material on intracellular expression of peptides, bioactivity of the cell-penetrating peptides
, and production and purification of the monomeric recombinant peptide aptamers.
Wang's team attached cell-penetrating peptides
to molecules from cells of a skin cancer known as melanoma.
First-generation approaches to intracellular biologics, such as cell-penetrating peptides
, have not realized their full potential due to limited uptake of larger macromolecules into cells and limited tolerability.
Academic partners have unique knowledge and technologies on supercharged viral proteins-derived cell-penetrating peptides
(eg from Dengue virus) and ultra-resistant cyclic peptides that may be transferred to the industrial partners, which in turn have specialized proprietary technologies on anticancer and/or peptide drugs technologies.
It is the first product of a technology platform based on cell-penetrating peptides
and amino acid sequences derived from cyclin-dependent kinases (CDK).